Voldemort and his Death Eaters could be the main antagonists. They might see the unborn child as a threat and try to harm Lily or the baby. They could also be after some power that they believe the child will possess.
Perhaps some jealous witches or wizards who are envious of Lily's relationship with James and the upcoming baby could be antagonists. They might spread rumors or try to cause trouble for her during her pregnancy.
There could be an ancient dark magic entity that has awakened due to the special nature of Lily's pregnancy. This entity wants to use the unborn child for its own dark purposes and becomes the main antagonist. It could be something that has been dormant for centuries and is now attracted to the power of the baby.
Voldemort and his Death Eaters could be the main antagonists. Since they are against the wizarding world's light side, they would see Lily and James's unborn child as a threat, especially if there are prophecies surrounding the baby.
Perhaps some other characters who misunderstand Lily's 'insanity' could turn into antagonists. For example, if the Hogwarts faculty or some of her peers think she's a danger because of her erratic behavior, they might try to isolate or stop her, creating a sort of antagonistic relationship.
The Capitol could still be the main antagonists. They might see Katniss's pregnancy as a threat, either because they fear the child could grow up to be a symbol of resistance like Katniss or just because they want to maintain control over her. They could try to harm her or the baby in some way.
The main antagonists could be some of the other gods who are jealous of Aphrodite's special situation with Percy. For example, Hera might not like the idea of Aphrodite having a child with a demigod, as it goes against the normal order of things in the godly realm.
It could be an ex - partner of either Leah or Jasper. For instance, if Jasper has an ex - girlfriend who is jealous of Leah and the new baby, she might try to cause trouble between them. Maybe she spreads false rumors about Leah to make Jasper doubt her.
Their friends could also be antagonists in a sense. For example, if there's a friend who has always had a crush on Freddie and is jealous of Sam. This friend could spread rumors about Sam being a bad influence or try to convince Freddie that he's making a huge mistake by staying with Sam and having a baby. Another scenario could be that their friends don't take the situation seriously and keep pressuring them to act like they used to, which makes it hard for Freddie and Sam to focus on the pregnancy.
Another possibility is a group or organization that has different ideals. If Thalia and Luke are part of a group that values something different from them, that group could oppose their decision to have a child and become the main antagonists, trying to stop the pregnancy or take the baby away once it's born.
It could be Sharpay's over - controlling mother who is more concerned about her daughter's image and career than the pregnancy. She might try to convince Sharpay to take certain actions that are not in the best interest of the baby or Zeke.
Lex Luthor could be a great antagonist. He might see the unborn children as a threat to his power and plans for world domination. He could try to steal the babies' powers while they're still in the womb or manipulate events to cause harm to Barry and Kara during their pregnancies.
Well, it could be certain political rivals. Maybe there are those who fear that the child of Korra and Iroh will have a strong claim to leadership or influence in the future. So, they become the antagonists, trying to create problems for the couple during the pregnancy. It could also be some dark spirits or entities that sense the special nature of the unborn child and want to prevent it from being born, seeing it as a potential obstacle to their own dark purposes.