There's a chance that the main antagonist is a mysterious figure who has a vendetta against Naruto's ideals. This figure could be from Naruto's past, perhaps someone he unknowingly wronged during the war, and now wants revenge.
It could be a rogue ninja who took advantage of the chaos during the war. This ninja might have been gathering power in the shadows and now sees Naruto as a threat to his plans.
Madara Uchiha could be a great antagonist in this kind of fanfiction. He has the power and the ambition. He could manipulate the war game from behind the scenes, perhaps using his Sharingan to control the minds of some of the participants. He wants to reshape the ninja world according to his own vision, and the war game provides him with an opportunity to do so without directly confronting all the ninja forces at once.
It could be a power - hungry shinobi from another village. This shinobi sees Naruto's exile as an opportunity to gain more power and influence in the ninja world. He might try to hunt Naruto down to prove his own strength or to steal Naruto's secrets.
Perhaps a secret organization within the Hidden Leaf that wants to take over the village. They use Naruto as a scapegoat, getting him banished so they can carry out their evil plans without interference from Naruto. They would be the main antagonists as they are the ones behind the false accusations and the push for his banishment.
Perhaps a new, unknown force. With Naruto gone, a previously hidden group with a vendetta against the ninja villages could emerge. They might blame the villages for the destruction caused during the war and see Naruto's death as the perfect time to strike, when the villages are still recovering and vulnerable.
Sakura could be a main character. She might be the one who helps Naruto deal with his emotional and physical wounds after the war. She could also be struggling with her own feelings towards Naruto now that he's back.
It could be a new villain who has been plotting against Konoha while Naruto was away.
Madara Uchiha might also be a main antagonist. His goals of reshaping the ninja world could be directly opposed to what Naruto is trying to achieve with his newfound 'godlike' powers. Madara would likely see Naruto as a major obstacle in his grand plan for the shinobi world.
It could be a long - lost relative of Orochimaru. This person might have been secretly studying Orochimaru's forbidden jutsu and developed even more terrifying techniques. They could be seeking revenge on the ninja world for ostracizing Orochimaru.
It could be some of the traditionalist elders in the Hidden Leaf. They might see Naruto as a threat even after the war, fearing his growing power and influence, and thus engineer his banishment. So they could act as antagonists as Naruto tries to find his place outside the village.
A new dark entity could be the main antagonist. This entity might have been awakened by Naruto's return from the dead. It could be something that was sealed away long ago and Naruto's return breaks the seal. The entity would then target Naruto and his loved ones to prevent him from getting in its way of ruling the ninja world.