One possible plot could be the little sister being a source of emotional support for Gaara. Since Gaara had a tough childhood, his sister could help him heal his inner wounds and show him the love he always craved. For example, she might encourage him to open up more to his friends in the village.
Maybe the story could revolve around Gaara protecting his little sister. He, with all his power as a shinobi, would be extremely protective. Their relationship could grow as he teaches her ninjutsu and she in turn helps him become more in touch with his softer side.
One possible plot could be that the little sister has a special power. For Naruto, she might be a ninja with unique jutsu. In the Sekirei world, she could be a Sekirei with a new type of ability. Maybe she gets caught in the middle of a conflict between the two worlds, and Naruto and the Sekirei have to work together to protect her.
One possible plot could be that Gaara is the new student in high school and Sakura is assigned to show him around. They start off as strangers but gradually become friends as they face common high school problems like bullies or difficult exams. Then, they might realize they have deeper feelings for each other.
One possible plot could be that Naruto's twin sister is also a jinchuriki. She might have been hidden away in a different way than Naruto. For example, while Naruto was ostracized in the village, she could have been raised in secrecy by an ally of the Fourth Hokage. As they grow up, they both discover their connection and together they strive to change the perception of the villagers towards them. They could also train together and unlock new jutsu that combine their unique abilities.
The plot could involve the sister seeking revenge for some harm done to their family or clan. Maybe their family was wronged by a rival village or a group within Konoha. She might use her ninja skills, which could be unique like a special jutsu passed down in the family, to take on her enemies one by one. For example, if their parents were killed by a group of rogue ninjas, she would hunt them down across the ninja world, with Naruto initially being unaware of her motives but eventually getting involved to protect her.
One possible plot is that his sister could have a special power that attracts the wrong kind of attention. Naruto then has to use his influence as a hero in the village to keep her safe. Maybe she is also trying to prove herself as a capable ninja despite being in Naruto's shadow.
The little sister could also be a key in uniting different factions in the TMNT universe. For example, she might befriend some of the Foot Clan members who are tired of Shredder's tyranny. Her innocent nature could make them see a different side of life. And with the help of her turtle brothers, they could work together to bring peace to the city. It would be a great plot twist and a way to explore new relationships in the TMNT world.
Well, perhaps Bella's sister is a half - vampire herself. She was born from a vampire who didn't fully turn her mother. This sister could struggle with her identity, not fully fitting in with either humans or vampires. She might be drawn to the Cullens because of their 'vegetarian' lifestyle but also be scared of them. She could also be friends with Jacob before Bella even arrives in Forks, and Jacob has to keep her secret from Bella until the right time.
Well, perhaps the twin sister has the power to see the future more clearly than Merlin. This ability could put her in a tricky situation as she tries to prevent certain disasters from happening without revealing too much. Or she could be a healer, and her skills are needed when a deadly plague hits Camelot. Since she's Merlin's twin, there would be a strong bond between them, and she might sacrifice herself to save Merlin at some point.
One plot idea could be that Harry's sister is secretly a powerful witch with unique abilities. For example, she might have the power to communicate with magical creatures in a way no one else can. This could lead to her getting involved in a plot to save a rare and endangered magical creature that is being hunted by dark wizards. Another idea is that she discovers a hidden prophecy related to her and Harry that changes the course of their fight against Voldemort. She could be the key to a new spell or magic that can defeat Voldemort once and for all.
The plot could be about Naruto's little brother growing up in Naruto's shadow. He might struggle to find his own identity while constantly being compared to Naruto. Maybe he has different ninja abilities that are overlooked at first because everyone is so focused on Naruto's power.