I think Ian from Shameless and Jude from The Fosters would make an interesting pair. Ian has his own struggles with his identity and relationships, and Jude is also on a journey of self - discovery. They could bond over their shared experiences of not always fitting in with the mainstream. They might start a support group for LGBTQ+ youth in their combined neighborhood.
Inuyasha and Ariel would be an interesting pair. Inuyasha is a rough - around - the - edges half - demon, while Ariel is a curious and adventurous mermaid. Ariel could be fascinated by Inuyasha's otherworldly appearance and his sword, and Inuyasha might be intrigued by Ariel's ability to swim and communicate with sea creatures. They could team up to face a threat that endangers both the sea in the Disney world and Inuyasha's forest in his world.
I think Naruto and Lucifer would be an interesting pair. Naruto's unwavering belief in good and his never - give - up attitude would contrast sharply with Lucifer's more cynical and self - centered nature. Their interactions could be full of tension and also moments of mutual understanding as they learn from each other.
Thor and a Dwarf Lord would be really interesting. Thor with his god - like powers and his hammer Mjolnir could team up with a Dwarf Lord, who is known for his skill in forging and combat. They could exchange stories about their great battles and also work together to create some powerful weapon, perhaps using Asgardian and Dwarven forging techniques.
Mulan and the twins from 'Twitches'. Mulan is a brave and resourceful warrior. The twins have their own unique magical abilities. They could team up in a battle against an evil force that is threatening both their worlds. Mulan could teach the twins some combat skills, and the twins could use their magic to give Mulan an edge in battle, like creating magical distractions or enhancing her weapons.
Hellboy and Wolverine would be a really interesting pair. Wolverine's feral nature and regenerative abilities combined with Hellboy's brute strength and demonic heritage would make for some great action scenes. They could have some really cool banter too, with Wolverine's gruff attitude and Hellboy's dry sense of humor.
Wonder Woman is another great choice. Her strong moral code and powerful abilities would be an interesting counterpoint to Deadpool. He might be in awe of her at first, and then start trying to crack jokes and get on her nerves, but they could also form an unlikely friendship as they fight together against a common enemy.
I think Spider - Man and Harley Quinn could be a really interesting pair. Harley's chaotic nature and unpredictable behavior would mix well with Spider - Man's sense of responsibility. They could start off as unlikely allies, with Harley initially trying to play tricks on Spider - Man but then realizing they have a common enemy and working together in a really unique way.
Edward Cullen and The Flash would make for an exciting pair. Edward has his vampire powers, including super - strength and enhanced senses. When combined with The Flash's super - speed, they could be an unbeatable team. Imagine them racing against each other at first, testing each other's limits, and then realizing they can achieve more together. Also, Edward's brooding nature and The Flash's more upbeat and positive attitude would create a great contrast in the story.
Sherlock and Italy would be an interesting pair. Italy is often portrayed as a bit scatter - brained and carefree in Hetalia, which would contrast sharply with Sherlock's intense and focused nature. Their interactions could be both comical and lead to some interesting plot developments as Sherlock tries to get Italy to focus on the case at hand. Another interesting pair could be Sherlock and Germany. Germany's discipline and order could either clash or complement Sherlock's methods, and they could have a great dynamic when it comes to solving a mystery together.
Thor and Godzilla would be an interesting pair. Thor, with his god - like powers and his hammer Mjolnir, could potentially have a showdown with Godzilla. It would be a clash of different kinds of power - Thor's lightning and brute strength against Godzilla's atomic breath and massive size.