Another possibility is a corrupted version of one of Sonic's friends. Maybe through some dark influence, like an evil Chaos Emerald, a friend turns on Sonic and blinds him. This would add an extra layer of drama as Sonic has to deal not only with his blindness but also the betrayal of someone he trusted.
Dr. Eggman could be the antagonist. He's always trying to defeat Sonic, and shooting him could be part of one of his evil plans. Maybe he developed a new weapon specifically designed to take Sonic down.
It could also be a new villain. Maybe someone who has been waiting for Sonic to be in a vulnerable state. This new villain could have a special power or weapon that is more effective against Sonic as a kid. For example, a device that can slow down Sonic even more or nullify his powers temporarily. They might target Sonic not just because of his weakened state, but also because they know that his friends will be distracted trying to help him get back to normal.
Dr. Eggman and Dr. Wily could team up. Dr. Eggman has his mechanical creations and knowledge of Sonic's world, while Dr. Wily is an expert in creating powerful robots in Mega Man's world. Together, they could be a formidable force against Sonic and Mega Man.
Dr. Eggman would be an obvious choice. Since Sonic is now in a more vulnerable human form, Eggman could see this as the perfect opportunity to finally defeat Sonic and take over the world. He might come up with new devious plans, like creating robots specifically designed to target a human Sonic.
Dr. Eggman would be a likely choice as he often causes trouble for Sonic. In the context of Secret Wars, he could have found a way to connect Sonic's world to other dimensions and start the wars to finally defeat Sonic once and for all. He might be using new and powerful machines he has created from the combined technology of different dimensions.
Dr. Eggman could be a great main antagonist. He could be using the chaos of war to further his own plans for world domination. He might be creating powerful war machines and using them to take over different regions, forcing Sonic and his friends to fight back to protect the peace.
A new character could be introduced as the main antagonist. For example, a being from another dimension who has been observing both Sonic's and Megaman's worlds. This being realizes that by combining the chaos energy from Sonic's world and the advanced robotics technology from Megaman's world, it can create a new, all - powerful empire. So it starts to manipulate events in both worlds to bring about this combination, while Sonic and Megaman have to stop it.
Well, obviously Dark Gaia itself could be the main antagonist. It has the power to cause chaos and destruction, and Sonic would have to stop it from wreaking havoc on the world.
Maybe the main antagonist is an old enemy of Robin's who becomes jealous of his new powers. This enemy then devises a plan to steal Robin's powers or at least neutralize them so that he can regain his former status as the top threat. He could be a powerful martial artist or a criminal mastermind with a large network of henchmen.
Maybe an evil artist from another dimension. This artist is jealous of Nathanael's pure creativity and the unique power of his miraculous. They come to Nathanael's world to steal his ideas and use his miraculous for their own dark purposes, like creating chaos and destruction through art.