There are a great number of 1850 novels, and without more context or extensive research, it's difficult to say. It could be that it's a very specific or even a made - up reference. Some well - known 1850 novels include 'The Scarlet Letter' by Nathaniel Hawthorne, but I'm quite certain there are no crosswords in it let alone one with'mother of pearl' mentioned.
I'm not sure which 1850 novel specifically has a crossword with'mother of pearl' in it. There are many novels from that era, and it would require a lot of research to determine if there is such a combination in a crossword within a novel.
I'm sorry, but I really can't give a definite answer. Novels from 1850 are not typically known for having crosswords within them in the modern sense. And'mother of pearl' is not a common crossword entry in the context of a 19th - century novel. It might be a very niche or fictional situation that you've presented. If you can give more details about the type of novel or the context in which this crossword might exist, it would be more helpful.
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