What is a novel feedback loop architecture for optimizing protein functions?

Life in a fantastical world didn’t add up to everything Sylas thought it would be. There were no pretty ladies goading him, there were no overpowered items and abilities tossed his way, and there was no calm and peace. Instead, he was tossed directly into a hellhole some few hours before it was to be invaded. That was it, he figured. His fantasy adventure in another world would be a short-lived one. He’d die and that would be it. Except... You have died. A ‘Save Point’ discovered. Loading… You will be returned to the ‘Initial Save’ point. Read more on my Patreon: https://www.patreon.com/beddedO

"I will not die in this seventh life!" Rishe Irmgard Weitzner has had her engagement to the Crown Prince of the Hermity Kingdom annulled, but this is the seventh time it's happened; she's stuck within a time loop, where no matter the job she takes or location, she always ends up dead at 20, five years after the annullment. This time she catches the eye of Crown Prince Arnold Hein of the neighboring Galkhein Kingdom, which was the source of a world war, pestilence, resource depletion, and even direct murder in all her previous loops. Rishe accepts his proposal of marriage on the condition she doesn't have to perform royal duties, and gets to loaf around; also helps Arnold, as she fulfills his father's request to "technically" take a foreign fiancée/hostage. However, she soon starts using all her past life skills to help out the people of the Galkhein Kingdom and sees Arnold is not the same cold person as in her 6th loop; making Rishe wonder what made Arnold's heart grow cold. Disclaimer Note: This novel is written by Touko Amekawa. I do not own this novel and all the credit goes to Mrs.Touko Amekawa sensei. Author: Touko Amekawa Illustrator: Wan☆Hachipisu

#TIME LOOP #MYSTERY #PSYCHOLOGICAL # THRILLER #TAMAT --- Kazuki Amamiya menjalani kehidupan biasa sebagai peneliti di pusat teknologi waktu hingga suatu hari ia terjebak dalam "Loop Zero"—siklus waktu yang tidak seharusnya ada. Setiap kali hari yang sama terulang, jejak realitas semakin rusak, dan ingatannya mulai terkikis. Di tengah kekacauan, ia menemukan pesan misterius bertuliskan "ΔT_777", sebuah kode yang tampaknya menjadi kunci untuk mengakhiri loop yang mustahil ini. Bersama Rin Asagiri, rekan kerja yang cerdas namun menyimpan rahasia kelam, dan Shou Narukami, mantan insinyur jenius yang terobsesi pada teori konspirasi, Kazuki memulai pencarian jawaban di balik anomali ini. Mereka segera menyadari bahwa loop ini bukan kecelakaan—melainkan efek samping dari eksperimen terlarang yang menyentuh batas realitas. Namun, Loop Zero adalah awal dari sesuatu yang jauh lebih besar. Jika mereka tidak memecahkan teka-teki sebelum mencapai loop ke-777, waktu akan runtuh, dan eksistensi mereka akan terhapus selamanya. Dalam dunia yang terus mengulang dirinya sendiri, Kazuki harus menemukan kebenaran tersembunyi sebelum waktu benar-benar habis.

The apocalypse is not the end — it is a game. And only the elect can play along. Every week, a few chosen ones are placed in a twisted mirror of reality — a world on the brink of annihilation. Here, players must survive a new cataclysmic disaster, armed with only one randomly selected ability. Ethan Cross never asked to be a player. But when he is drawn into the Apocalypse Game, his first draw changes everything: "the Eye of Death" - an SSS-ranked ability that shows him visions of his own death. While others fight blindly, Ethan outwits fate itself and replays his own demise until he finds the perfect path to victory. "Congratulations! You have overcome the disaster of [Puppet Kingdom] and obtained the [Severing Seven]: [The Severing Seven]!" "Congratulations! You've eliminated the threat of [Abyssal Horror] and received [S-Rank Ability: [Abyssal Horror]: [S-Rank Skill: Scales of Judgment]!" "Congratulations! You have shattered the paradox of [Time Reversal] and unlocked the [SSS Rank Skill: Sword of Destruction]: [SSS Rank Skill: Sword of Annihilation]!" Other players: "Bro, we’re still learning the rules, how can you clear dungeons already?" Apocalypse Control Bureau: "Mr. Cross, your survival is crucial to the future of humanity! STOP THROWING YOURSELF INTO DANGER!"

This story is of a boy named Akatsuki. His adventures and his misfortune and his redos. He is really indecisive and he is not about to become the strongest. Enter the mysterious entity named The Author. He suddenly appears before everyone and reboots the whole story. What will happen in this reboot? Will it be the same or different from before?

Book Summary: Time Loop Bank In a world where time is the ultimate currency, the Time Loop Bank controls the most powerful resource known to humanity—the ability to borrow, trade, and manipulate time itself. Those who are wealthy extend their lives indefinitely, while the desperate gamble their futures for a fleeting second chance. Ethan Carter, once known as Caleb in the underworld, wakes up in a hidden facility after a near-fatal betrayal. His former identity, erased. His past, buried. But the one thing he cannot escape is the debt that binds him to the system. He once thought he was playing the game, but now he realizes he was just another piece on the board. As Ethan unravels the truth behind the Time Loop Bank, he discovers a conspiracy that stretches far beyond crime syndicates and corrupt officials. The elite aren’t just buying time—they’re rewriting history, shaping reality itself. And at the center of it all is a hidden force manipulating the flow of time for its own agenda. Armed with stolen data and pursued by those who would rather see him dead than let the truth out, Ethan must navigate a world where every second counts. He is no longer just a survivor—he is the only person who can break the cycle. But to do so, he must outplay the system, confront the ones who control time itself, and make the ultimate gamble: risk everything or be erased from existence. Themes: • Time as Currency: The book explores a world where time is traded like money, and those who control it dictate reality. • Power and Corruption: The elite manipulate time to maintain control, while the desperate are forced into impossible choices. • Identity and Survival: Ethan must shed his past and redefine himself to escape the system that has already written his fate. • Conspiracy and Rebellion: The deeper he digs, the more he realizes that even time itself is being rewritten to serve an unseen force. Genre: A blend of cyberpunk, sci-fi thriller, and high-stakes conspiracy, Time Loop Bank is a story of survival, deception, and the fight for control in a world where the future is up for sale.