One idea could be to cross Vampire Hunter D with a post - apocalyptic world setting from another series. D could be on a quest to find a vampire lord who has the key to a cure for a virus that has decimated humanity. He would face both vampires and mutated creatures along the way.
A crossover with a steampunk world would also be cool. D could be in a city filled with steam - powered machines and dirigibles. The vampires in this world could have adapted to use steampunk technology to their advantage, and D would have to use his skills and newfound steampunk gadgets to combat them.
A crossover with "Castlevania" would also be cool. D could find himself in the world of Castlevania, dealing with the various dark creatures there. He might have to navigate the complex politics between the vampires and the humans in that universe.
Perhaps there could be a character in the Harry Potter world who has vampire - like abilities and is mistaken for a real vampire. D is called in to deal with this 'vampire' but realizes it's not a normal vampire case. He and Harry then have to figure out what's really going on. It could involve a dark wizard's experiment gone wrong that created this half - vampire - half - wizard creature, and they need to find a way to reverse it or at least keep it from causing harm.
A plot could be Doris discovers a hidden vampire lair near her village and decides to take matters into her own hands before D arrives. She could use her knowledge of the local area to her advantage and try to set traps for the vampires. This would show her courage and resourcefulness.
The clash of different power systems would be really interesting. D has his superhuman strength, speed, and the ability to use his left hand for various powers, while the wizards in Harry Potter have magic. How would they interact? For example, would D's powers work against magical creatures in the wizarding world? And how would the wizards react to D's unique abilities? It could create some really cool battle scenes and moments of discovery.
One idea could be to cross it with the Harry Potter universe. The dhampirs could attend Hogwarts and learn magic along with their combat training. They might have to deal with vampires who are also interested in the power of magic. Another idea is to cross it with the Twilight universe. Imagine the different vampire clans from Vampire Academy interacting with the Cullens. It could lead to some interesting power struggles and cultural clashes.
One idea could be to cross it with another supernatural show like 'Teen Wolf'. The characters from both could team up to fight a common enemy, like an ancient and powerful vampire - werewolf hybrid. For example, Elena could use her charm and vampire skills, while Scott McCall could lead his pack in the fight.
One possible plot could be that Vampire Hunter D and Van Helsing team up to hunt a powerful vampire that has been terrorizing both their worlds. D's unique dhampir abilities combined with Van Helsing's knowledge and skills would make for an exciting adventure.
One idea could be that Harry Potter discovers a hidden world within the wizarding realm where Vampire Hunter D's technology and lore exist. He teams up with D to fight a new breed of vampires that are immune to normal wizarding spells. This would blend the magic of Harry Potter with the dark, post - apocalyptic feel of Vampire Hunter D.
One idea could be to cross Initial D with another racing anime like 'Wangan Midnight'. The characters from both could compete in a huge underground racing event that combines the unique terrains and racing styles of both series.
Perhaps the fanfiction could explore a friendship between the little vampire and a human who discovers his secret. They could go on adventures together, with the human helping the vampire understand human emotions better, and the vampire using his powers to protect the human from danger.