One possible plot could be that Edward, now as a girl, has to deal with the different reactions of his friends. For example, Alphonse might be a bit confused at first but quickly adapts and becomes very protective. Edward could also face new challenges in his alchemical studies as some traditional alchemy is male - dominated. And he might have to struggle with his own self - identity, trying to figure out if he still has the same goals and values as before the transformation.
A possible plot is that Edward's transformation into a girl causes chaos in the military. Some people might try to take advantage of his new form, while others are more sympathetic. He has to navigate through this political mess while also trying to find a way to reverse the transformation. Along the way, he discovers new aspects of his alchemy that were hidden before because he was always thinking from a male perspective. He might also have to deal with unwanted romantic advances from some characters who are attracted to his new female appearance.
Well, a cool plot could be that Edward as a girl gets involved in a different kind of adventure. Maybe she's underestimated by her opponents because she's now female. But she uses this to her advantage, like getting closer to an enemy who doesn't see her as a threat. She could also start to see the world from a different perspective, especially in terms of relationships with other characters. For instance, she might develop a new friendship with a female character who was previously just an acquaintance.
Perhaps a new alchemist who is jealous of Edward's skills, even in his new form. This antagonist might see Edward as a girl as an easy target to discredit. They could spread rumors about how Edward's transformation has made him less capable in alchemy, when in fact it's just their way of trying to undermine him.
Well, perhaps there's a plot where Edward, as a girl, has to keep his true identity a secret. This could lead to some really tense and comical situations. Like when his friends from before start showing different kinds of interest in him, not knowing it's really Edward. And he has to figure out how to interact with them without giving away his secret while also trying to find a way to turn back into his original self.
Obviously, Edward Elric himself is the central character in this type of fanfiction. His brother Alphonse might also be a common character, often trying to help Edward deal with his new situation. Winry Rockbell could be there too, perhaps having a different kind of relationship with Edward now that he is a girl. There might also be the appearance of some of the villains from the original story, who could either take advantage of Edward's new form or be involved in the reason why he turned into a girl in the first place.
Edward's intelligence. He is a brilliant alchemist. A fanfic could explore how he shares his knowledge with the reader, perhaps teaching the reader alchemy. This could lead to some really interesting adventures where they use alchemy to solve problems in their world. And the reader could also bring out a different side of Edward as he gets closer to someone who is not as experienced in alchemy as he is.
Often, one interesting plot point is how Bella acquires the knowledge or power to turn Edward. Maybe she discovers an ancient spell or some new vampire lore. Another point could be Edward's initial reaction. He might be shocked, angry, or even a bit excited at the prospect of a new existence.
In this fanfiction, her role as an alchemist might be perceived differently. As a girl, she might face more discrimination in the male - dominated field of alchemy. This could lead to stories of her having to prove herself more often and in different ways than in the original story.
In this fanfiction, the plot could center around Edward trying to understand and control a mysterious new type of energy. He could be on a quest to find the source of this energy. Along the way, he meets new characters, some of whom help him while others try to stop him from achieving his goal of mastering this energy.
One possible plot could be that Edward Elric discovers Ki as a new form of energy. He might initially struggle to understand and control it, like he did with alchemy. He could meet a mentor who teaches him the basics of Ki, and then he uses this new knowledge to face his enemies in a different way, perhaps even combining Ki with his alchemy skills.
Well, perhaps Edward could use his alchemy skills in the magical world of Hogwarts. He might be sorted into Gryffindor for his courage. He could start to learn magic along with the Hogwarts curriculum and have some interesting interactions with the students like Harry, Hermione and Ron. Maybe he'd show them some unique alchemy tricks and in turn learn some new spells.
Well, one possible plot could be that Deku accidentally drinks a strange potion created by a villain. This potion has the side - effect of changing his gender to female. At first, he's shocked and confused. But then, he realizes that he can use this new form to his advantage in hero work. For example, he might be able to infiltrate a female - only villain group more easily. He also has to deal with his friends' reactions, some are surprised while others are supportive and help him adjust to his new body while still being a hero.