It could be a new god or goddess who has risen to power during Percy's long sleep and sees him as a threat to their rule. This new deity might be jealous of Percy's past heroics and fame among the demigods and wants to eliminate him.
One possible plot could be that when Percy wakes up after centuries, he finds the world he knew completely changed. Maybe all his friends are long gone and he has to deal with a new set of demigods who see him as a relic from the past. He might struggle to adapt to the new technology and social structures.
It could be the warden of the prison. The warden might be a cruel and power - hungry person who wants to keep Percy imprisoned for his own reasons, like getting some sort of reward or power from those who put Percy there.
A powerful dark sorcerer could be the main antagonist. He might be seeking to use Percy's skills for his own evil purposes, and when Percy refuses, he becomes the target. The sorcerer would have a vast array of dark magic at his disposal, making him a formidable foe.
A powerful demigod who has been corrupted by the idea of primordial power could be the main antagonist. They might believe that by allying with a primordial or obtaining their power, they can become greater than the gods. This demigod would then oppose Percy, who stands for the protection of the current order.
Perhaps a powerful and corrupted demigod could be the main antagonist. This demigod might be jealous of Artemis' power and popularity among the other demigods. He devises a plan to harm her, and Percy, being loyal to Artemis, has to give his life to save her from this rogue demigod.
A powerful Amazonian sorceress who has turned against her own kind and is now trying to use dark magic to take over the world. She could see Percy as an obstacle in her path and constantly try to defeat him.
Maybe a rogue demigod who blames Percy for something and wants to make his exile permanent. This demigod could have some dark powers or be in league with some evil forces. They would constantly try to thwart Percy's attempts to return or find a way to clear his name.
It could be a character who wants to use Percy - turned - Aku for their own evil purposes. Maybe a dark wizard who thinks that Aku - Percy can be the ultimate weapon to take over the world. This wizard would try to manipulate Percy's new form and powers to do his bidding.
Maybe an ancient sea demon that has possessed a pirate captain. This possessed captain is now leading his crew to cause chaos everywhere. They are attacking other pirate ships and even some demigod - related places. Percy has to find a way to exorcise the demon from the captain and stop the crew's rampage. The demon is very cunning and uses the pirate's knowledge of the sea to its advantage.
The main antagonist might be a new character, a powerful being that rules the realm where Percy is banished. This being could see Percy as a threat to his or her power and try to stop Percy from finding a way back.