There could be new characters introduced as part of Naruto's family. For instance, a young girl from a foreign land who Naruto saves during a mission. She could have no family left and Naruto decides to take her in. She could bring a fresh perspective to Konoha and to Naruto's life, with her different cultural background and unique abilities.
It could be some hidden members of Naruto's family itself. Maybe there are relatives who have been manipulating things from the shadows and their actions led Naruto to believe he needs to take revenge on the family as a whole.
In the fanfiction, Naruto might think his family abandoned him on purpose. So, he starts to seek revenge. He could train hard to become extremely powerful. Along the way, he meets some people who try to convince him that revenge is not the answer. But his anger is so strong that he doesn't listen at first. Eventually, he might come across some evidence that shows his family had no choice but to leave him, which makes him question his revenge mission.
Perhaps a family of magical scholars. They would expose Harry to all kinds of ancient magic texts and theories. This would make Harry not only a better wizard in terms of practical magic but also in understanding the deeper roots of magic. They could be the ones to finally unlock the full potential of Harry's magic, which was stunted by his difficult upbringing at the Dursleys.
I think it could be an old, retired ninja who has a passion for fashion. This ninja has seen many battles and knows what kind of clothes would be practical for Naruto. He would use his experience and knowledge to design clothes that are not only stylish but also enhance Naruto's abilities. For example, he could add some special seals into the fabric that can store chakra or protect Naruto from certain types of attacks. And he might also incorporate some elements from Naruto's past adventures into the design, like using the pattern of a beast he once fought against.
His friends like Ron and Hermione could be part of it. They've been through so much together, and after the war, they might decide to live close to each other and consider each other family. They could raise their children together and share holidays as one big family.
It could be a family of pure - blood wizards who have been observing Harry's situation from afar and decide to take him in. They might see his potential and want to groom him into a great wizard.
One possible reason could be that he has some unresolved issues from his past, like the absence of his parents during his childhood which made him feel a sense of detachment. Maybe he is so focused on achieving his ninja goals that he unconsciously starts to ignore his family. Another reason might be some sort of miscommunication within the family. For example, if there are secrets that the family has been keeping from him, he might feel betrayed and thus choose to ignore them.
One possible reason could be a long - held misunderstanding. Maybe Naruto discovers some family secrets that he misinterprets as betrayal or neglect. For example, if he finds out that his family had made some sort of pact that he disagrees with, it could lead to his rejection.
It could be Orochimaru. He has always been interested in power and the secrets of the tailed beasts. So, he might see Naruto and the Jinchuuriki family as a source of great power to experiment on or steal from.
Obviously, Naruto himself would be one of the main characters. His wife, for example Hinata, would also be a main character as she is part of his family. And their children, like Boruto and Himawari, would surely play important roles too.