Perhaps an ancient evil entity that was once sealed away but is now breaking free. It wants to destroy all the good in both of their worlds, and Feyre and Aelin are the only ones who can stop it. The entity would be extremely powerful, with abilities that can counter both Feyre's and Aelin's powers to some extent.
One interesting plot could be that Feyre and Aelin team up to face a common enemy that threatens both of their worlds. They combine their unique powers and skills, like Feyre's ability to shapeshift and Aelin's fire - magic, to defeat the foe.
One likely antagonist could be a disgruntled former Stark Industries employee. This person has access to some of Iron Man's old tech and uses it to create chaos. They might target Peter Parker too because he's associated with Iron Man now.
It could be a new group of survivors who are extremely territorial. They see Rick's group and Clementine as threats to their resources. This group might be led by a power - hungry man who is willing to do anything to protect what he thinks is his, including attacking Rick's group and trying to capture Clementine.
It could be a powerful dark wizard from Harry's world who has escaped into Wednesday's world to hide and cause chaos. This wizard might be attracted to the darker and more accepting atmosphere of Wednesday's world and use it as a base to plan his evil deeds. He could try to use the strange and spooky elements in Wednesday's world to create powerful dark magic, and Harry and Wednesday would have to join forces to stop him.
It could be a new Sith Lord. This Sith Lord has been secretly amassing power in the shadows and now aims to destroy the last remnants of the Jedi. His dark powers pose a great threat to Rey and Ahsoka, and they must use all their skills and the Force to defeat him.
A powerful dark wizard or sorcerer could be the antagonist. He might be after the Saiyan's life - force or some special energy that Gohan and Bardock possess. This wizard could use dark magic to create all sorts of obstacles for them, like illusions, cursed landscapes, and powerful minions.
Another possible antagonist could be a rogue ninja from Hailbel's past. This ninja could have a vendetta against her family or something she did in the past. When he discovers that Hailbel is with Naruto, he decides to take them both on. He might have some unique and dangerous techniques that Naruto and Hailbel have to figure out how to counter.
A possible main antagonist could be a powerful dark wizard who has somehow learned about the existence of the demigod world and wants to harness the power of the demigods for his own evil plans. He could be jealous of the unique abilities that Percy and Annabeth possess and see them as a threat to his rule in the wizarding world.
It could be the Red Queen. She might see Alice's presence in Mirana's world as a threat to her own power and try to stop their friendship.
Kingpin would be a great antagonist. He already has a history with Daredevil and his criminal empire could easily draw in Spiderman as well. He could use his wealth and influence to create all sorts of problems for the two heroes, like funding new super - villains or using his political connections to turn the public against them.