Alphys could be another common character. As the royal scientist, she might be called upon to figure out what's wrong with Sans. She could bring her scientific knowledge to the table, trying to diagnose and find a cure. Her own insecurities might play a role here too, as she might be worried about failing to help Sans.
Papyrus would be a great addition. His relationship with Sans could take on a whole new dynamic when Sans becomes human. Papyrus might be overprotective at first, not sure how to deal with his now - human brother. He could also be a source of comic relief as he tries to understand human behaviors.
Another possible main character could be Frisk. Since Frisk has a connection with Sans, they would be involved in Sans' story when she becomes a girl. Frisk could be the one who first discovers Sans' transformation and helps her come to terms with it, or they could be on an adventure together with Sans in her new form.
One plotline could be how the other characters in the story react to Sans being sick. For example, Papyrus might be overly worried and try all sorts of crazy remedies. Another could be Sans trying to hide his sickness because he doesn't want to be a burden.
One common theme is sacrifice. Sans often gets hurt while protecting someone or something he cares about, like his friends or the Underground. It shows his selfless nature.
His friends like Batman and Nightwing could be main characters. Batman might use his detective skills to figure out what's wrong with Robin, and Nightwing could be there to offer emotional support.
If it's in a work - related setting, his boss or colleagues could be significant characters. His boss might be understanding and give him time off to recover, or his colleagues could be worried about how his absence will affect the work, which could create some interesting plot points.
Since Rigby is sick, his family members could also be main characters in the fanfiction. They might come to visit him and bring their own unique family drama to the story. And his friends from the park, like Muscle Man and High Five Ghost, could also be involved, trying to cheer him up while he's ill.
One common theme could be the contrast between the sick reader's vulnerability and Fresh Sans's more energetic or carefree nature. It might explore how the two interact in that state of the reader being sick.
Chica could also be a main character. She could be the one who tries to comfort Bonnie while he's sick. Maybe she brings him some virtual food or something to cheer him up. And Foxy might be another important character. He could be the one who goes on adventures to find a cure or a way to fix Bonnie. He's the more adventurous type, so it would make sense for him to be the one looking for solutions outside the normal areas in the pizzeria.
Even the kids who visit the pizzeria could be main characters. They might be the first to notice that Foxy is acting strange. One of the kids could be really attached to Foxy and be very worried about him. This kid could try to get the staff's attention to help Foxy or even try to comfort Foxy on their own.