In the fanfic, it could be that Sasuke doesn't appreciate Sakura enough. She might pour out her love and support for him, but he doesn't return it in the way she hoped. Sakura may have expected a more reciprocal relationship where her feelings are acknowledged and valued. Since that's not the case, she starts to regret her choice of Sasuke.
Maybe in the fanfic, Sasuke has some personality traits that become more difficult for Sakura to handle over time. For example, his brooding nature might start to feel like emotional unavailability rather than just his usual self. This could lead to her regret.
In the fanfiction, perhaps Sasuke has a hard time expressing his emotions. Sakura might feel unloved or unappreciated in the marriage. She may have expected more emotional connection and when it doesn't happen, regret sets in.
In the fanfic, Hermione might regret choosing Ron over Harry because Harry has a different level of understanding when it comes to her academic pursuits. Harry, having faced the challenges of fighting Voldemort from a young age, might have a deeper respect for Hermione's thirst for knowledge and her need to constantly learn and improve. Ron, on the other hand, sometimes showed impatience with Hermione's studious nature.
One possible reason could be that Sakura has finally grown tired of Sasuke's aloof and cold behavior towards her. She might have realized that she has been constantly chasing after him while getting little in return, so she decides to ignore him as a form of self - preservation.
Maybe in the fanfic, Ron's laziness becomes more pronounced over time. Hermione is highly ambitious and hard - working, and she might find Ron's lack of drive frustrating, making her regret her choice.
This fanfic can make the relationship look more realistic. In real life, relationships often have problems. By having Sakura regret choosing Sasuke, it shows that even in a fictional world based on Naruto, relationships can be full of doubts and second - thoughts. It might also change the perception of Sasuke as not being the ideal partner for Sakura, as his actions and attitude might be shown in a less favorable light in the fanfic.
It could be because of a dark power corrupting Sasuke. Maybe an ancient evil force takes over him and makes him see Sakura as an enemy. In some fanfics, this kind of external influence can completely change a character's actions. Also, it might be related to Sasuke's pursuit of power. If he believes Sakura is standing in the way of his ultimate power - seeking goal, he could be driven to kill her.
Maybe to explore different character arcs. The writer might want to see how Sakura would develop as a character if she strayed from her loyalty to Sasuke. It could also be a way to introduce new characters or relationships into the Naruto fanfic world.
One possible reason could be Sasuke's focus on his revenge. His thirst for vengeance against Itachi might make him blind to Sakura's feelings and neglect her as he is constantly preoccupied with getting stronger to achieve his goal of revenge.
Perhaps Sasuke was testing Sakura's loyalty or strength. He may have thought that if she couldn't withstand his aggression, she wasn't worthy of being in his life. Also, his own inner demons, like the hatred he carried from his past, could have flared up and led him to almost kill her without fully realizing what he was doing.