It could be Voldemort. He might have cast a new spell on Harry that makes him cough blood as part of his ongoing attempts to defeat Harry.
Maybe a new dark wizard or witch has emerged. They see Harry as a threat and use a strange, blood - related dark magic on him. This new antagonist could be someone who has a personal vendetta against Harry for some past deeds.
Well, perhaps it could be about Harry being injured in a battle and coughing up blood. Maybe he's in a fight with a dark wizard and gets seriously hurt.
It could be a long - lost relative of Voldemort. Maybe a distant cousin or something who has the same thirst for power and has decided to target Harry and his friends to gain more influence in the wizarding world.
Perhaps a long - lost relative of the Potter family who feels they were unjustly excluded from inheriting the manor. This relative could be jealous of Harry's status and the wealth associated with the manor. They might use dark magic to try and claim what they think is rightfully theirs, leading to a battle of magic and loyalty within the Potter family and among Harry's friends.
Maybe there could be a new antagonist, a dark shapeshifter who is jealous of Harry's power. This antagonist could be an old wizard who has been in hiding for centuries, waiting for the right time to emerge and take over the wizarding world. He sees Harry as a threat to his plans and tries to eliminate him.
Another possibility is a corrupted member of the Ministry of Magic. They might be trying to use Harry as a scapegoat to gain more power within the Ministry. They could be working with the Death Eaters or acting on their own, but they would be a significant obstacle for Harry as he tries to stay alive and free while on the run.
Perhaps a new dark wizard or witch who has infiltrated the Ministry of Magic and made sure Harry was sent to Azkaban. This antagonist could be working towards a bigger plan to take over the wizarding world and sees Harry as a major threat even when he's locked up.
It could be Voldemort. He might see Harry's new waterbending ability as a threat and try to find a way to counter it. Maybe he would seek out dark magic related to fire to oppose Harry's water powers.
It could be a new dark wizard who has risen to power. This wizard might see Harry as a threat to his plans, so he manipulates the situation to get Harry exiled.
Another possibility is a corrupted magical creature that has been influenced by dark magic from the 'sociates'. This creature could be intelligent and manipulative, causing chaos among the students at Hogwarts and the wizards in the 'sociates'. It would be difficult to defeat as it has unique abilities that are not well - known to either group.
It could be an ancient dark magic artifact. The artifact has a hold on Bellatrix, and in a way, it's the 'enemy' that Harry has to defeat to save her. The artifact might be trying to use Bellatrix to carry out some dark plan, like opening a portal to a world full of dark creatures. Harry has to figure out how to break the connection between Bellatrix and the artifact while also fending off the artifact's attacks.