When does Itachi die in the manga?

Yes, Itachi does die in the manga.

Ace dies during the Marineford War arc. It's a tragic moment in the manga.

Itachi's story comes to an end in the Naruto manga and anime during a significant plot point.鍏蜂綋鐨勬椂闂磋妭鐐逛細鍥犵増鏈拰涓汉鐞嗚В鏈夋墍宸紓銆

Itachi's story concludes when certain truths about his actions and sacrifices are revealed, which occurs at a critical point in the Naruto storyline. It's a poignant and impactful moment.

Sure. Itachi's saving of Sasuke was a crucial moment in the manga. It was tied to his hidden motives and sacrifices for the greater good of the ninja world and Sasuke's future.

I'm not sure. You might have to read the manga yourself to find out for sure.

Yes, it does. The manga delves into Itachi's backstory to explain his motivations and actions.

Sorry, I don't know exactly when Carl dies in the comics. You might need to look through the specific issues to find out.

Glenn meets his demise in the comics during a particularly intense and chaotic event. The circumstances surrounding it are quite harrowing and have a significant impact on the story's direction.

I'm not sure exactly when Amuro dies. It might vary depending on the specific novel series you're referring to.