Perhaps a plot where Spiderman and She - Hulk are framed for a crime they didn't commit. They have to go on the run while trying to clear their names. Along the way, they discover that a powerful criminal organization is behind the frame - up. This organization is trying to take over the city's underworld. Spiderman uses his stealth and intelligence, and She - Hulk uses her brute force to fight back against the organization's minions. They also have to deal with the public's distrust of them as they are now seen as criminals.
One interesting plot idea could be that Hulk and She - Hulk have to team up to fight a new super - villain who is immune to their individual powers. They must learn to combine their strengths in a new way. Another could be a story where they accidentally swap powers and have to deal with the consequences. For example, She - Hulk might struggle with Hulk's lack of control at times, while Hulk has to adjust to She - Hulk's more refined fighting style.
One idea could be that they team up to face a new super - villain who is immune to normal Hulk - like strength. So, they have to combine their smarts and unique Hulk - related abilities in a new way. Another could be a story where they explore their family connection in a more in - depth way, like dealing with the implications of being related Hulks in a world that still doesn't fully understand them.
A plot could revolve around a scientific experiment gone wrong that affects only them. They start to lose control of their powers in different ways. Hulk might become too calm and lose his rage - fueled strength, while She - Hulk might turn into her human form at the wrong times. They have to work together to reverse the effects of the experiment, all while dealing with the problems that come with their power - changing states.
One idea could be that She - Venom has a unique connection to Spider - Man's spider - sense. Maybe her symbiotic abilities interfere with it in unexpected ways, leading to some comical or dangerous situations as Spider - Man tries to adapt. Another could be a story where She - Venom and Spider - Man have to team up to stop a new super - villain who is immune to the regular attacks of both of them, forcing them to combine their powers in creative ways.
One idea could be a story where Spiderman has to team up with his greatest enemies to fight a new, more powerful threat from outer space. This would force him to put aside his differences and find common ground with the likes of Doctor Octopus and Green Goblin.
One idea could be that She - Hulk and Daredevil team up to take on a powerful new villain in Hell's Kitchen. The villain could be a corrupt lawyer who uses legal loopholes to get away with crimes, and She - Hulk's legal expertise along with Daredevil's street - fighting skills make them the perfect duo to stop him.
A third plot might be that a spell gone wrong in the wizarding world creates a rift that pulls She - Hulk into it. She then has to find a way back home while also getting involved in the ongoing struggle between the good wizards led by Harry Potter and the dark forces. Along the way, she could use her legal knowledge (since she's also a lawyer) to help resolve some disputes within the wizarding community that are related to new magical laws.
One idea could be that Spiderman discovers Rachnera in a part of the city that's been affected by some strange scientific experiment gone wrong. He initially mistakes her for a villain but soon realizes she's just trying to find her way in this new world. They could team up to fight against the real bad guys who are behind the experiment.
One plot idea could be that Spiderman and Silk team up to face a new super - villain who has the ability to manipulate time. They have to use their combined skills and their unique spider - sense in different ways to outwit the villain. Another could be a story where they explore their relationship more deeply while on a mission in an alternate dimension.
Another plot could involve a mad scientist who creates a device that can drain the powers of superheroes. He first targets Superman, but Spiderman gets involved when he sees the chaos in Metropolis. As they try to stop the scientist, they discover that the device has a side effect of giving the heroes new, unexpected powers for a short time. They have to quickly learn to control these new powers while also dealing with the main threat.