Perhaps Orochimaru's experiment accidentally releases an ancient evil that was sealed long ago. Naruto, being the hero he is, takes it upon himself to reseal the evil. Along the way, he discovers secrets about his own family and the origin of chakra that are linked to Orochimaru's experiment.
One idea could be Orochimaru taking an unexpected interest in Naruto's growth not for his power but for his unique way of seeing the ninja world. Maybe Orochimaru starts to secretly guide Naruto in some unorthodox ways of chakra control, which Naruto initially resists but later realizes could be useful.
One plot idea could be Orochimaru finding a way to truly achieve immortality that doesn't involve body - hopping. Maybe he discovers an ancient jutsu that links his soul to the very essence of the ninja world. Another idea is Orochimaru teaming up with Naruto to face a new, greater threat, and in the process, Naruto starts to understand Orochimaru's pursuit of immortality from a different perspective. And perhaps Orochimaru could create a new form of immortality that is more about passing on his knowledge and skills in a unique way rather than just living forever physically.
One idea could be an experiment on new jutsu creation. For example, Naruto and his friends could be part of a research project to combine different elemental jutsus in unique ways. Another could be an experiment on the limits of chakra control, like seeing how much chakra Naruto can store in a new type of seal.
Maybe in the fanfiction, Naruto gets trapped in one of Orochimaru's old experiments. Female Orochimaru, out of curiosity about Naruto's power and his unique personality, decides to study him up close. But during this time, Naruto manages to show her the value of human connection and kindness, which she has long forgotten, leading to a deep bond between them.
A plot could involve Orochimaru using his knowledge to help Naruto unlock a new power, but in the process, they get closer than expected. As they train together, their interactions become more intense and personal. Naruto's positive influence gradually changes Orochimaru's view of the world, and they end up on a journey together to face a common enemy that only their combined skills can defeat.
One plot idea could be Orochimaru seeing some potential in child Naruto that is different from the Nine - Tails. Maybe he wants to train Naruto in a different form of jutsu, not for evil but for some self - serving yet not completely malicious purpose. For example, he could be interested in Naruto's ability to make friends and wants to use that to his advantage in the ninja world.
One idea could be exploring what would happen if a character was given multiple bloodlines through an experiment. For example, combining the Sharingan and Byakugan. This could lead to a whole new set of abilities and challenges for the character. They might struggle to control the conflicting powers or find unique ways to use them in combat.
Some fanfictions in this genre might deal with the idea of using genetic experiments to revive extinct ninja clans. Imagine bringing back the Uzumaki clan in a new form through genetic manipulation. There could also be the idea of using genetic experiments to counteract the effects of certain curses or seals. For example, if a character has a seal that limits their power, genetic experiments could potentially find a way to break or modify that seal. Additionally, the idea of cross - species genetic experiments, like combining ninja genetics with that of some mythical beasts in the Naruto universe, could lead to really unique and exciting storylines.
In some 'naruto bloodlines experiment fanfiction', there could be the concept of a failed bloodline experiment that leads to a character having unpredictable powers. This can add a lot of drama and mystery to the story as the character tries to control or understand these new abilities. Also, the fanfic might explore how different characters react to this new and potentially dangerous situation.
One interesting idea could be Orochimaru seeing Naruto as a unique specimen and instead of just trying to use him, he actually starts to respect Naruto's willpower. This could lead to a strange mentorship of sorts where Orochimaru teaches Naruto some of his more unorthodox jutsu in exchange for Naruto trying to help Orochimaru find a new path that doesn't involve so much darkness.