Harry Potter himself could be the main character. He could be the one who stumbles into the world of Bioshock. His magical abilities would be put to the test against the threats in Rapture.
Hermione Granger and Bella Swan could also be main characters. Hermione could bring her intelligence and knowledge of magic, while Bella could provide insights into the Twilight world. They might start off as rivals, with Hermione thinking Bella is too naive and Bella finding Hermione too bossy, but then they grow to respect each other and work together.
Definitely Harry. He could form a special bond with a particular Pokegirl, maybe a fire - type Pokegirl, and they could go on adventures together in the wizarding world. Ron could also be a main character. He might be a bit more hesitant about the Pokegirls at first but then grow to like them. And there could be a new character, a Pokegirl trainer who comes to Hogwarts to introduce the concept of Pokegirls to the wizards, and she becomes an important part of the story.
Chef Ramsay would be the central figure. Then perhaps Hagrid could be a character. Hagrid is always dealing with magical creatures and he could provide some very interesting and unique ingredients for the kitchen. Also, Neville Longbottom could be there. He has a love for plants, and he could contribute by providing fresh magical herbs for cooking. And of course, the Hogwarts head chef, who would be resistant to change at first but gradually learn from Ramsay.
Well, it could be that a dark wizard in the Harry Potter universe discovers the ADAM and plasmids from Bioshock. He starts using them to create an army of super - powered Death Eaters. Harry and his allies have to figure out how to counter this new threat. They might travel to Rapture to find a way to neutralize the ADAM or find some kind of magical antidote. Harry could use his Patronus charm to fend off the more deranged splicers, and the Weasley twins could use their prank - making skills to mess with the Big Daddies.
Horus himself would be a central character. He would bring his own set of powers and a whole different mythology into the story. Dumbledore could also play a significant role. He's wise and powerful, and he might have some knowledge about Horus or the connection between the two worlds. Maybe he's been waiting for Horus to arrive for some greater purpose. And then there could be some minor characters like Neville Longbottom who could end up being unexpectedly helpful in the journey.
A powerful dementor - like being that has been corrupted by Asgardian dark magic. This entity could be draining the life force of both wizards and Asgardians. It would be up to Thor and Harry Potter to find a way to stop it, as it poses a threat to both of their worlds.
A plot could involve Voldemort learning about the power of ADAM in Bioshock. He sees it as a way to gain ultimate power and sends his Death Eaters to Rapture to steal it. Meanwhile, a group of Aurors follow them, and then there's a three - way battle between the Aurors, Death Eaters, and the denizens of Rapture.
Voldemort could also be a main character in a different sense. He might be the one causing the misery in a way that combines the horror elements of 'Misery' with his own brand of dark magic. Or, a character from 'Misery' like Annie Wilkes could be the main antagonist against the Harry Potter characters, using her non - magical but still very dangerous means to torment them.
Hermione could be a great main character. She has a thirst for knowledge and could be very interested in the Tudor era. She might travel back in time to study the magic of that period. Another option could be Henry VIII. He could be a character who discovers some magic from the Harry Potter world and tries to use it to his advantage in his court.
Harry Potter himself could be the main character. He has the experience of dealing with all kinds of dark and strange things, so he would be a natural fit to face the FNAF animatronics in the crossover. He could use his magic skills like the Patronus charm to fight against any dark influence the animatronics might have.